As Ozempic use surges among women seeking fast weight loss, an unexpected side effect is drawing attention—along with a significant price tag. Some are reportedly paying more than $2,500 for cosmetic procedures aimed at restoring sagging or deflated intimate tissue after sudden fat loss.
Even though Ozempic has been repeatedly highlighted as not intended for weight loss, millions of people worldwide continue using it off-label to drop pounds.
The medication was originally developed to help control blood sugar in people with Type 2 diabetes. As a GLP-1 and GIP receptor agonist, it has also become widely known for producing dramatic weight-loss results.
Unexpected changes
But dramatic results can come with noticeable consequences, and the latest reported issue has gone viral online under labels like “Ozempic vulva” or “Ozempic vagina.”
This is not an officially listed side effect from the drug’s manufacturer, but medical professionals are starting to comment on what they are seeing.
“If you’re using a GLP-1, and you’re losing weight too rapidly, it’s going to have a massive impact on the tissue and muscles everywhere,” said Kathy Kates, a nurse practitioner and pelvic floor specialist, in comments to USA Today. “People talk about ‘Ozempic face.’ It’s the same thing. You’re losing fat, you’re losing tissue integrity, and all those things matter for a healthy pelvic floor.”
Dr. Michael Tahery, a Los Angeles-based urogynecologist, has also explained on his website that rapid fat loss may affect the vulva in several ways. These can include sagging of the outer labia, weakened vaginal muscles, and increased dryness—changes that may be linked to a weakened pelvic floor and can contribute to symptoms such as bladder leakage and pain during intercourse.
In short, the drug does not target fat in only one part of the body—it can reduce fat stored in the abdomen as well as fat in more delicate areas.
‘Aged look’
“Loss of subcutaneous fat is global – including the mons pubis and labia majora – sometimes giving the area a deflated or ‘aged’ look. This can be due to ptosis of soft tissue, or atrophy of the fat in this area,” said Dr. Justin Perron, a board member of the Australasian Society of Aesthetic Plastic Surgeons, in an interview with the Daily Mail.
Beyond appearance, gynecologist Dr. Melanie Bone told Newsweek that “rapid weight loss induced by GLP-1 agonists may alter hormone levels, which could affect vaginal lubrication and tissue health. Some women may experience increased vaginal dryness as a result.”
Solutions
Dr. Paul Banwell told LADBible that as Ozempic becomes more widely accessible, interest in corrective cosmetic procedures has grown. These treatments are designed to address visible volume loss, as the labia majora and minora may appear more wrinkled, saggy, or hollow after major fat reduction.
Reported treatment options include:
Labiaplasty: For women dealing with sagging skin after Ozempic-related weight loss, labiaplasty is described as a surgical procedure to reshape and tighten the labia minora and majora. Dr. Tahery writes that it has a satisfaction rate above 90% and is often sought after childbirth or as part of aging-related changes, with some patients reporting improved confidence and comfort in tight clothing.
Vaginal tightening: Significant weight loss may be associated with vaginal laxity, reduced sensation, and dryness. Vaginal tightening procedures are promoted as a way to restore firmness, improve intimacy, and potentially ease incontinence, sometimes alongside aesthetic enhancements.
Labia puffing: When weight loss leaves the labia looking wrinkled or deflated, labia puffing aims to restore volume using dermal fillers (similar to facial injections and typically described as having minimal downtime) or fat grafting, which uses the patient’s own fat for a more natural and potentially longer-lasting result.
Vaginal dryness relief: Ozempic-associated dryness is also being addressed with non-hormonal creams such as SILK, which are marketed as a way to restore moisture and comfort without prescriptions or procedures.
Increased corrective procedures
“I have definitely noticed a rise in procedures on the back of rapid weight loss from Ozempic and other GLP-1s. More women have been enquiring about labiaplasty and labial puff procedures,” Banwell said.
Procedures aimed at Ozempic-related vulvar changes are not covered by the NHS and are generally treated as cosmetic, with costs often starting at $2,500 USD or more for labial puffing and labiaplasty, depending on clinic and location.
It is also important to note that the medical community has not formally studied “Ozempic vagina” as a defined condition. Still, anecdotal reports and increasing cosmetic consultations suggest it may be a real concern for a subset of patients experiencing rapid, significant weight loss.
While the medical value of GLP-1 medications like Ozempic in managing obesity and diabetes is widely recognized, the growing focus on aesthetic side effects underscores a broader conversation about body composition changes that can accompany rapid weight reduction.
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