Louise Altese-Isidori, 50, was living a healthy, active life and often received compliments on how well she looked. Unbeknownst to her, she was battling Stage 4B ovarian cancer—a disease often called a “silent killer” because early symptoms are rare.
Her diagnosis came thanks to a routine transvaginal sonogram, a precaution she followed on her fertility doctor’s advice. Although another physician told her it was unnecessary, Louise chose to continue annual scans—a decision that likely saved her life.
In October 2024, a large ovarian cyst was detected. Two Ova1 blood tests came back negative for cancer, but her surgeon didn’t like the ultrasound results and urged immediate surgery. On December 20, what was expected to be a standard ovary removal turned into a life-saving operation when doctors discovered cancer spread to her colon, liver, chest, and other organs.
At Memorial Sloan Kettering Cancer Center, Dr. Dennis Chi removed her spleen, appendix, gallbladder, uterus, ovaries, fallopian tubes, and stomach lining, along with parts of her liver and colon. Louise endured 18 days in the hospital, chemotherapy, and temporary use of a colostomy bag.
Now, her CA 125 levels are normal, her hair is growing back, and she is technically in remission. Still, with recurrence rates as high as 95% for Stage 4 cases, she takes a PARP inhibitor to delay the cancer’s return.
Louise hopes to “redefine the face of stage four cancer,” reminding others that even in advanced stages, life can still be full of hope and purpose.
Warning signs of ovarian cancer can include bloating, fatigue, pelvic or abdominal pain, and changes in bowel or bladder habits.
