ST.Silencing One Brain Gene May Reverse Autism Deficits
Summary: Researchers uncovered a precise molecular mechanism to restore NMDA receptor (NMDAR) hypofunction, a core pathology in autism spectrum disorder (ASD). The research shifts focus away from traditional, highly toxic systemic targets toward Slc6a20a/SLC6A20, a glycine transporter heavily localized within cognition-related brain regions like the cortex and hippocampus. Utilizing antisense oligonucleotides (ASOs) in adult mouse models…
