Summary: Researchers uncovered a precise molecular mechanism to restore NMDA receptor (NMDAR) hypofunction, a core pathology in autism spectrum disorder (ASD). The research shifts focus away from traditional, highly toxic systemic targets toward Slc6a20a/SLC6A20, a glycine transporter heavily localized within cognition-related brain regions like the cortex and hippocampus. Utilizing antisense oligonucleotides (ASOs) in adult mouse models…
Summary: Researchers uncovered a precise molecular mechanism to restore NMDA receptor (NMDAR) hypofunction, a core pathology in autism spectrum disorder (ASD). The research shifts focus away from traditional, highly toxic systemic targets toward Slc6a20a/SLC6A20, a glycine transporter heavily localized within cognition-related brain regions like the cortex and hippocampus. Utilizing antisense oligonucleotides (ASOs) in adult mouse models…
You’re brushing your teeth, you’re half-awake, and then something darty and creepy creeps across your bathroom floor as if it owns it. Gross. Been there. If you see these little guys often, you may have a silverfish problem. Yep — those shiny, squirmy bugs that kind of look like a fish mixed with a bug…
The laundry wringer on that crowded table was more than a curiosity; it was a surviving fragment of a world built on muscle, patience, and shared effort. Its worn handles and iron rollers hinted at long days when washing clothes meant hauling water, scrubbing until knuckles burned, and talking with neighbors while steam rose into…
If you’ve ever noticed a tree with its lower trunk painted white, there’s more to it than decoration. This common practice among gardeners and orchard owners serves an important protective purpose. Sudden temperature swings in winter, from cold nights to sunny days, can cause bark to split—a condition known as sunscald. Painting the trunk with…
Not everyone communicates through language. Finding alternative ways to bond is simpler than you may think. Cheyenne Buckingham, right, and her sister at home in Columbus, Ohio, in 1999. (Brook Buckingham) Column by Cheyenne Buckingham From a young age, I realized that my connection with my sister was fundamentally and profoundly different from my peers’ relationships…
The morning started so normally that I never could have predicted how quickly my imagination would spiral into panic. Sunlight stretched across the apartment floor in long golden strips while the city outside slowly came alive with distant traffic and muffled sounds from neighboring balconies. Still half asleep, I wandered into the kitchen, made coffee…
Not everyone communicates through language. Finding alternative ways to bond is simpler than you may think. Cheyenne Buckingham, right, and her sister at home in Columbus, Ohio, in 1999. (Brook Buckingham) Column by Cheyenne Buckingham From a young age, I realized that my connection with my sister was fundamentally and profoundly different from my peers’ relationships…
Turning 70 should be a celebration of experience, freedom, and the opportunity to enjoy retirement. But for many drivers across the UK, this milestone could also bring an unexpected surprise that threatens their ability to stay on the road. Thousands of motorists may be unaware that reaching the age of 70 can automatically affect certain…
In the evening, I came home completely exhausted after a long and stressful day. All I could think about was finally getting into bed, pulling the blanket over myself, and enjoying a few hours of uninterrupted sleep. My body felt heavy, my mind was drained, and I barely had enough energy to turn on the…